Protein A Resin Market, By Product Type (Agarose-based Protein, Glass or Silica-based Protein, Organic Polymer-based Protein), Application (Antibody Purification, Immunoprecipitation), End User (Pharmaceutical and Biopharmaceutical Companies, Research Laboratories, Others), and region (North America, Europe, Asia-Pacific, Middle East and Africa and South America). The global Protein A Resin market size was estimated at USD 1.12 billion in 2023 and is projected to reach USD 1.89 billion in 2030 at a CAGR of 7.8% during the forecast period 2024-2030.
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Monoclonal antibodies are pivotal in modern drug development, particularly for oncology, autoimmune, and infectious diseases, necessitating robust purification methods. This has led to increased demand for protein A resins. For instance, a 2023 report by the Society of Biological Engineering Journal highlighted the surge in protein A resin demand due to the biopharmaceutical industry's need for efficient purification methods.
Regional Analysis:
North America emerged as the largest region in 2023. Pharmaceutical companies, research institutions, and government organizations in North America are channelling substantial investments into research and development activities, spurring the development of new biopharmaceuticals and driving the demand for Protein A Resin. Additionally, the growing biosimilars market, driven by cost-effectiveness and healthcare affordability concerns, has created a surge in demand for Protein A Resin.
Key Findings
· On the basis of Product Type, the agarose-based protein A segment held a significant share of the market in 2023. This resin is extensively utilized in the biopharmaceutical and biotechnology industries due to its versatility, efficiency, and reliability. Agarose-based protein A resin offers a high binding capacity for antibodies, facilitating the purification of large quantities of proteins in a single run. Its stability across a wide range of pH and salt conditions allows for adaptability to various purification protocols, ensuring robust and reliable results.
· On the basis of Application, Antibody purification emerged as the largest segment in 2023. Protein A resin, engineered for capturing and purifying antibodies with remarkable specificity and efficiency, plays a crucial role in producing high-quality, therapeutically effective monoclonal antibodies. It achieves exceptional purity levels by removing contaminants and aggregates, resulting in antibodies with minimal impurities.
· On the basis of End User, the pharmaceutical company's segment is poised for substantial growth during the forecast period, driven by the increasing utilization of Protein A resin. This trend highlights the resin's critical role in the purification processes of biopharmaceutical products.
· The market is also divided into various regions such as North America, Europe, Asia-Pacific, South America, and Middle East and Africa. North America led the global market with approximately 38% share in 2023, driven by significant investments in monoclonal antibodies, a robust biopharmaceutical industry, and strong R&D capabilities.
Competitive Landscape
· Abcam PLC.
· Agilent Technologies
· Bio-Rad Laboratories, Inc.
· Danaher Corporation
· EMD Millipore
· Expedeon Ltd
· GE Healthcare
· GenScript Biotech Corp.
· Merck Millipore
· Novasep Holdings SAS
· PerkinElmer, Inc.
· Purolite Life Sciences
· Repligen Corp.
· Thermo Fisher Scientific Inc.
· Tosoh Bioscience
· Agarose Bead Technologies
· Axplora
· Kaneka Corporation
· JSR Life Science
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The pharmaceutical and biopharmaceutical companies are anticipated to dominate the protein A resin market, primarily due to their extensive use of proteins in drug discovery and development. Protein analysis is crucial for target identification, efficacy and toxicity biomarker identification, and understanding drug mechanisms, which is fueling market growth amidst numerous ongoing drug development projects globally. Government funding and technological advancements in analytical instruments further drive this segment's growth.
Additionally, strategic agreements and expansions, such as Purolite's extended agreement with Repiligen Corporation and Ecolab Inc.'s new biologics resin manufacturing facility, highlight the industry's response to the growing demand. The competitive and fragmented nature of the protein A resin market sees major players continually introducing innovative products and forming partnerships to maintain a market edge.
Recent Developments
In February 2024, Purolite, now part of Ecolab, collaborated with Repligen Corporation to announce the commercial release of Praesto CH1, a new 70 μm agarose-based affinity resin tailored for purifying specialized monoclonal antibodies, including bispecifics and recombinant antibody fragments.
In January 2024, Dutch Oxitope and Norwegian Arxx announced their merger to establish Calluna Pharma Inc., focusing on the development of monoclonal antibody therapies targeting inflammatory and fibrotic diseases. The newly formed company successfully raised USD 80.4 million (EUR 75 million) in Series A financing to advance its clinical-stage lead program, CAL101. CAL101 is a monoclonal antibody designed to neutralize the bioactivity of S100A4 and is currently undergoing Phase 1 trials for indications related to fibrosis and inflammation.
The Report helps to identify the opportunities in Global Regions:
· North America (the United States, Canada, and Mexico)
· Europe (Germany, UK, France, Italy, Russia, Turkey, etc.)
· Asia-Pacific (China, Japan, Korea, India, Australia, and Southeast Asia (Indonesia, Thailand, Philippines, Malaysia, and Vietnam))
· South America (Brazil etc.)
· The Middle East and Africa (North Africa and GCC Countries)
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