Before exploring future directions, it’s essential to understand how Avanafil works. As a PDE5 inhibitor, Avanafil blocks the enzyme phosphodiesterase type 5, which is responsible for degrading cyclic guanosine monophosphate (cGMP). cGMP plays a crucial role in relaxing the smooth muscle cells in blood vessels, thereby allowing them to dilate and increase blood flow. In the case of ED, this results in improved erectile function. Avanafil is often compared to other PDE5 inhibitors, such as sildenafil (Viagra) and tadalafil (Cialis).

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